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Examining the Potential Side Effects of Ozempic for Weight Loss

In recent months, medications intended for type 2 diabetes and clinical obesity, such as Ozempic, Wegovy, and Mounjaro, have become increasingly popular on social media as drugs for quick weight loss.[0] Despite the widespread use of these drugs, there is still a lot of uncertainty surrounding the safety and effectiveness of them.

In 2017, the U.S. Food and Drug Administration gave their approval of Ozempic as a treatment for Type 2 diabetes when in conjunction with diet and exercise if other medications fail to adequately regulate blood sugar levels.[1] Although Ozempic has not been officially approved for long-term weight control, it can be prescribed for off-label use and used safely by those who are overweight.[2]

Approximately one-third of individuals who utilize Ozempic for weight reduction have been shown to experience a loss of ten percent or more of their body weight.[3] However, the drug’s manufacturer, Novo Nordisk, warns against off-label use, as the drug may become less effective over time, leading to some weight regain.[4]

Patients may also experience a side effect known as “Ozempic face,” which Frank, a New York City-based dermatologist, coined.[5] Patients who have experienced a major weight loss may notice changes in their facial appearance, known as “Ozempic face”. This includes a loss of facial fat, which can cause the face to appear sagging or aged.[6] It’s especially common in middle-aged and older patients.[7]

“Fat in the face helps us maintain a naturally youthful appearance,” says Joshua Zeichner, M.D., director of Cosmetic & Clinical Research in Dermatology at Mount Sinai Hospital.[8] “When you lose facial fat, the face often appears gaunt and skeletonized. Especially in people who lose large amounts of weight, the face can appear significantly older.”[3]

In the end, it is important to remember that Ozempic and other similar drugs should be used only with the approval of a medical professional. While these drugs are effective, it is still important to consider the possible side effects, including Ozempic face.[6]

0. “”Ozempic Face”: The Latest Side Effect From Taking Weight Loss DrugsHelloGiggles” HelloGiggles, 25 Jan. 2023,

1. “What Is Ozempic Face? Woman Who Lost 68 Pounds on Diabetes Medication Says Her Face Felt Like It ‘Was Melting'” Inside Edition, 27 Jan. 2023,

2. “What it’s like to take Ozempic and Wegovy, from severe side effects to 50-pound losses” AOL, 29 Jan. 2023,

3. “Doctors warn about ‘Ozempic face’ side effect of medications” The Independent, 27 Jan. 2023,

4. “Here’s What Actually Happens When You Stop Taking Ozempic” Yahoo Life, 27 Jan. 2023,

5. “What Is Ozempic Face? Some Using Diabetes Drug for Weight Loss Report This Side Effect” NBC New York, 26 Jan. 2023,

6. “What to Know About ‘Ozempic Face'” Healthline, 27 Jan. 2023,

7. “Woman details experiencing ‘Ozempic face’ after losing 68 pounds on the drug” Yahoo! Voices, 27 Jan. 2023,

8. “What Is ‘Ozempic Face,’ the Side Effect Everyone Is Talking About?” Yahoo News, 26 Jan. 2023,

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