Sleep Me

Study Finds Extracorporeal CPR No Better Than Conventional for Out-of-Hospital Cardiac Arrest

A study published in the Jan. 26 issue of the New England Journal of Medicine has found that for patients with out-of-hospital cardiac arrest, extracorporeal cardiopulmonary resuscitation (CPR) does not improve favorable neurologic outcome compared with conventional CPR.[0] The study was conducted in the Netherlands and was funded by the Netherlands Organization for Health Research and Development and Maquet Cardiopulmonary (Getinge).[1]

160 patients aged 18 to 70 years with an out-of-hospital cardiac arrest who had received bystander CPR, had an initial ventricular arrhythmia, and did not have return of spontaneous circulation within 15 minutes after initiation of CPR were randomly assigned to receive extracorporeal CPR (70 patients) or conventional CPR (standard advanced cardiac life support) (64 patients).[0] Survival with favorable neurologic outcome at 30 days was the primary outcome, which was defined as a Cerebral Performance Category score of 1 or 2 (1 to 5, with higher scores indicating greater disability).[0] The intention-to-treat basis was used for the analysis.[1]

The results of the study showed that 20 and 16 percent of patients in the extracorporeal CPR and conventional CPR groups, respectively, were alive with a favorable neurologic outcome at 30 days (odds ratio, 1.4; 95 percent confidence interval, 0.5 to 3.5; P = 0.52).[0] The amount of serious adverse events reported per patient was similar between the two groups.[0]

For those who are already subscribers, they can verify their print or online subscription account here.[2] Full week print subscribers are entitled to FREE unlimited online and eEdition access through the Shelbyville News All-Access.[2] For those who are not yet subscribers, they can choose from a variety of subscription options, including one month access, one year access, and online digital subscription.

0. “Extracorporeal CPR Does Not Offer More Favorable Neurologic Outcome” FOX Bangor/ABC 7 News and Stories, 25 Jan. 2023,

1. “Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest | NEJM”, 25 Jan. 2023,

2. “Extracorporeal CPR Does Not Offer More Favorable Neurologic Outcome” Shelbynews, 25 Jan. 2023,

Sleep Me